Correlates of Nonanemic Iron Deficiency in Restless Legs Syndrome

Ferric carboxymaltose in patients with restless legs syndrome and nonanemic iron deficiency: A randomized trial

BACKGROUND Compromised iron status is important in restless legs syndrome pathophysiology. We compared the efficacy and tolerability of ferric carboxymaltose (single intravenous dose) versus placebo for restless legs syndrome treatment in iron-deficient nonanemic patients. METHODS Patients with moderate to severe restless legs syndrome and serum ferritin < 75 μg/L (or serum ferritin 75-300 μg...

Prevalence and correlates of restless legs syndrome in chronic renal failure patients undergoing hemodialysis

Introduction: Restless legs syndrome (RLS) is a sensorimotor disorder characterized by an unpleasant sensation in the legs. This syndrome is a common, yet unrecognized, disorder. The aim of this project was to study the prevalence and correlations of RLS in chronic renal failure patients undergoing hemodialysis in Shahid Rahnemon hospital, Yazd (Iran). Materials and Methods: This descriptive cr...

Restless Legs Syndrome Prevalence in Major Thalasemia Tabriz Children Hospital

Reduction of R2 in the Basal Ganglia of Restless Legs Syndrome: a Biomarker for Iron Deficiency

Introduction: Restless legs syndrome (RLS) is a neurological disorder with a prevalence of about 5-10% of the general population. Its clinical symptom is characterized by uncontrollable, unbearable urges to move the legs, causing chronic sleep deprivation. The iron deficiency has been considered an important contributing factor for RLS [1]. In vivo iron evaluation for RLS has largely utilized T...

Profile of altered brain iron acquisition in restless legs syndrome.

Restless legs syndrome is a neurological disorder characterized by an urgency to move the legs during periods of rest. Data from a variety of sources provide a compelling argument that the amount of iron in the brain is lower in individuals with restless legs syndrome compared with neurologically normal individuals. Moreover, a significant percentage of patients with restless legs syndrome are ...